CD Markers for B-cell lymphoma
Below is a chart of the typical CD markers (cluster of differentiation) found
on most B-cell lymphomas. These are just one tool the pathologist uses to make a
diagnosis.
Click here for a chart of all CD markers and what they mean.
| Marker Status |
| Type |
CD5 |
CD10 |
CD19 |
CD20 |
CD21 |
CD22 |
CD23 |
CD43 |
CD79a |
sIg |
cIg |
| Follicular |
1 |
3 |
4 |
4 |
|
4 |
2 |
1 |
4 |
4 |
0 |
| Nodal marginal zone |
1 |
1 |
4 |
4 |
|
4 |
1 |
2 |
4 |
M4, D1 |
2 |
| MALT |
1 |
1 |
4 |
4 |
|
4 |
1 |
2 |
4 |
M4 |
2 |
| Splenic Marginal zone |
1 |
1 |
4 |
4 |
|
4 |
1 |
0 |
4 |
M4 |
2 |
| CLL/SLL |
4 |
0 |
4 |
4 |
|
4 |
4 |
4 |
4 |
D3 |
2 |
Lymphoplasmacytic
Waldenstroms |
1 |
1 |
4 |
4 |
|
4 |
0 |
3 |
4 |
M4, D2 |
4 |
| Mantle Cell |
4 |
1 |
4 |
4 |
|
4 |
1 |
4 |
4 |
M&D 4 |
0 |
Precursor B-cell
(lymphoblastic) |
4 |
3 |
4 |
4 |
|
4 |
0 |
0 |
4 |
0 |
0 |
| Diffuse large B-cell |
2 |
2 |
4 |
4 |
|
4 |
0 |
1 |
4 |
|
|
| Mediastinal large cell |
2 |
|
|
|
|
|
|
|
|
|
|
| Burkitt's |
1 |
4 |
|
|
|
|
|
|
|
|
|
| Intravascular B-cell |
|
|
|
|
|
|
|
|
|
|
|
| Footnote: 0 = negative, 1 = <10%
positive, 2 10-50% positivity, 3 = 50-90% positivity and 4 = >90%
positive |
Sources:
Institute of Biomedical Science
http://www.ibms.org/pdf/pdf_science/lymphoma.pdf
H. Lee Moffitt Cancer Center and Research Institute
http://www.moffitt.org/moffittapps/ccj//v3n2/dept3.html
Medscape (note: article valid only until November 2007) Mantle Cell Lymphoma:
An Update for Clinicians CME)
http://www.medscape.com/viewarticle/548587_1
Pan B-cell markers are CD20, FMC7 and CD79b
http://www.karpuslab.northwestern.edu/Copy%20of%20CLL-CCC-2003.pdf
More on Pan B-cell markers (CD19, CD20, CD22, CD79a)
http://www.antibodybeyond.com/reviews/cell-markers/b-cell-marker.htm
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