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Older classifcation systems
Many classification systems have come and gone over the years. Here is a
brief history of them.
This classification was developed before lymphoid cells were divided into
B-cells and T-cells. It was developed in 1966 with the Lukes Collins
modifications in 1974
| Well-differentiated lymphocytic lymphoma |
small lymphocytic lymphoma |
| Poorly differentiated lymphocytic lymphoma |
6633 (NOS), 96643 (cellular phase) also:
96653 (HD NS, lymphocyte predominance)
96663 (HD NS mixed cellularity),
96673 (HD NS, lymphocytic depletion)
follicular center cell lymphoma with a large component of small-cleaved
cells. |
| Histiocytic lymphoma |
large cell lymphoma |
This was developed in 1974, the first to recognize B and T cell subtypes.
| B-cell |
T-cell |
| Low grade |
Low grade |
| *Lymphocytic -chronic lymphocytic and prolymphocytic
leukemia -hairy-cell leukemia |
Lymphocytic -chronic lymphocytic and prolymphocytic
leukemia |
| - |
Small, cerebriform cell -mycosis fungoides, Sézary's
syndrome |
| Lymphoplasmacytic/cytoid (LP immunocytoma) |
Lymphoepithelioid (Lennert's lymphoma) |
| Plasmacytic |
Angioimmunoblastic (AILD, LgX) |
| *Centroblastic/centrocytic - follicular ± diffuse -
diffuse |
T-zone |
| * Centrocytic |
Pleomorphicm, small cell (HTLV-1 |
| High grade |
High grade |
| Centroblastic |
Pleomorphic, medium and large cell (HTLV-1 ±) |
| *Immunoblastic |
Immunoblastic (HTLV-1 ±) |
*Large cell anaplastic
(Ki-1+ |
Large cell anaplastic (Ki-1+) |
| Burkitt's lymphoma |
- |
| *Lymphoblastic |
Lymphoblastic |
| Rare types |
Rare types |
This was developed by the National Cancer Institute in 1982 as a method of
translating among the recognized classification systems for non-Hodgkin lymphoma
(Rappaport, Dorfman, Lukes and Collins, Kiel, and the British Lymphoma system).
The major groups are identified by letters, A - J, and grouped according to
prognosis:
| Most favourable |
Low grade |
A, B, C |
| |
Intermidiate grade |
D, E, F, G |
| Least favourable |
High grade |
H, I, J |
| Low grade |
Intermediate grade |
High grade |
| Small lymphocytic |
Follicular large cell |
Large cell immunoblastic |
| Follicular small-cleaved cell |
Diffuse small cleaved cell |
Lymphoblastic |
| Follicular mixed small-cleaved and large cell |
Diffuse mixed small and large cell |
Small non-cleaved cell (Burkitt and non-Burkitt type)
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Diffuse large cell |
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Cell types categorized as unclassified by the Working Formulation include the
non-specific terms malignant lymphoma, non-Hodgkin lymphoma, diffuse malignant
lymphoma, nodular or follicular malignant lymphoma, and
cutaneous lymphoma.
Differences in histology refer to differences in the first 3 digits of the
ICD-O morphology code.
A simultaneous diagnosis of malignant lymphocytic lymphoma (small cell type)
and chronic lymphocytic leukemia (CLL) is coded to CLL
This system was used from 2001-2009 but replaced with the current 2008 WHO
classification system.
NOTE: The WHO adopted a new classification system for cutaneous
lymphomas. The classification system below is still the current one used, but it
will eventually be integrated with these new changes to the cutaneous lymphomas.
Click here to read
about the new cutaneous classification.
B-cell neoplasms
- I. Precursor B-cell neoplasm: precursor B-acute lymphoblastic
leukemia/lymphoblastic lymphoma (B-ALL, LBL)
- II. Peripheral B-cell neoplasms
T-cell and putative NK-cell neoplasms
(Hodgkin's disease)
- I. Nodular lymphocyte-predominant Hodgkin's lymphoma
- II. Classical Hodgkin's lymphoma
- A. Nodular sclerosis Hodgkin's lymphoma
- B. Lymphocyte-rich classical Hodgkin's lymphoma
- C. Mixed cellularity Hodgkin's lymphoma.
- D. Lymphocyte depletion Hodgkin's lymphoma
Back to the
current REAL/WHO classification system
Classification systems source information
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