Non Hodgkin's Lymphoma
Cyberfamily

Search    

Earlier classification systems

Many classification systems have come and gone over the years. Here is a brief history of them.

Rappaport and Lukes Collins
This classification was developed before lymphoid cells were divided into B-cells and T-cells. It was developed in 1966 with the Lukes Collins modifications in 1974

Well-differentiated lymphocytic lymphoma

small lymphocytic lymphoma

Poorly differentiated lymphocytic lymphoma

96633 (NOS), 96643 (cellular phase) also: 96653 (HD NS, lymphocyte predominance) 96663 (HD NS mixed cellularity), 96673 (HD NS, lymphocytic depletion)

follicular center cell lymphoma with a large component of small-cleaved cells.

Histiocytic lymphoma

large cell lymphoma

 


Kiel Classification
This was developed in 1974, the first to recognize B and T cell subtypes.

B

T

Low grade

Low grade

*Lymphocytic
-chronic lymphocytic and prolymphocytic leukemia
-hairy-cell leukemia

Lymphocytic
-chronic lymphocytic and prolymphocytic leukemia

-

Small, cerebriform cell
-mycosis fungoides, Sézary's syndrome

Lymphoplasmacytic/cytoid
(LP immunocytoma)

Lymphoepithelioid
(Lennert's lymphoma)

Plasmacytic

Angioimmunoblastic (AILD, LgX)

*Centroblastic/centrocytic
- follicular ± diffuse
- diffuse

T zone

*Centrocytic

Pleomorphicm,
small cell (HTLV-1

High grade

High grade

Centroblastic

Pleomorphic, medium and large cell
(HTLV-1 ±)

*Immunoblastic

Immunoblastic
(HTLV-1 ±)

*Large cell anaplastic (Ki-1+)

Large cell anaplastic (Ki-1+)

Burkitt's lymphoma

-

*Lymphoblastic

Lymphoblastic

Rare types

Rare types

 


Working Formulation
This was developed by the National Cancer Institute in 1982 as a method of translating among the recognized classification systems for non-Hodgkin lymphoma (Rappaport, Dorfman, Lukes and Collins, Kiel, and the British Lymphoma system). The major groups are identified by letters, A - J, and grouped according to prognosis:

most favorable

Low Grade

 A, B, C

 

Intermediate Grade   

 D, E, F, G

least favorable    

High Grade    

 H, I, J

 

Low Grade

Intermediate Grade

High Grade

Small lymphocytic

Follicular large cell

Large cell immunoblastic

Follicular small-cleaved cell

Diffuse small cleaved cell

Lymphoblastic

Follicular mixed small-cleaved and large cell

Diffuse mixed small and large cell

Small non-cleaved cell (Burkitt and non-Burkitt type)

 

Diffuse large cell

 

Cell types categorized as unclassified by the Working Formulation include the non-specific terms malignant lymphoma, non-Hodgkin lymphoma, diffuse malignant lymphoma, nodular or follicular malignant lymphoma, and cutaneous lymphoma.

Differences in histology refer to differences in the first 3 digits of the ICD-O morphology code.

A simultaneous diagnosis of malignant lymphocytic lymphoma (small cell type) and chronic lymphocytic leukemia (CLL) is coded to CLL

Back to the current REAL/WHO classification system

Classification systems source information


 

 

Home
Ask a Question

© 2006 NHL Cyberfamily All Rights Reserved.
Web design by
Long2 Consulting