Non Hodgkin's Lymphoma
Cyberfamily
CD marker chart
Below is a chart that shows the status of the various CD (Cluster of differentiation) markers for most types of Lymphoma.
Click here to read specific information on each CD marker
| Classification | B Cell Antigens | T Cell Antigens | Other Antigens | Genetic Features | ||||||
| CD19 | CD20 | CD22 | CD2 | CD3 | CD5 | CD7 | CD4 / CD8 | |||
| B Cell Lymphomas | ||||||||||
| Precursor B-lymphoblastic leukemia/lymphoma (B-LBL) | + | -/+ | + | - | - | - | - | - | CD10+/-; CD13 ps; CD33 ps; CD34+/-; HLADR+; sIg-; cytoplasmic mu -/+; TdT+ | Ig HC rg; Ig LC rg-ps; TCR rg (mn) |
| B-Cell Chronic Lymphocytic Leukemia (B-CLL)/ Prolymphocytic Leukemia (B-PLL)/ Small Lymphocytic Leukemia (B-SLL) | + | + | + | - | - | + | - | - | CD10-; CD11c-/+ (ft); CD23+; CD43+; sIgM ft; sIgD+/-; cIg-/+ | Ig HC & LC rg; +12 (33%); ab 13q (¾25%); t(11;14) & bcl-1 rg reported |
| Lymphoplasmacytoid Lymphoma | + | + | + | - | - | - | - | - | CD10-; CD11c ps (ft); CD25 ps (ft); CD43+/-; sIg+; cIg+; (us M); IgD- (us) | Ig HC & LC rg |
| Mantle Cell Lymphoma | + | + | + | - | - | + | - | - | CD10-/+; CD11c-; CD23-; CD43+; sIgM+; IgD+ (us); lambda > kappa; disorganized FDC | mj t(11;14) w/Ig HC & bcl-1 |
| Follicle Center Lymphoma, Follicular; Grades: I (Predominantly Small Cell); II (Mixed); III (Predominantly Large Cell); Provisional Subtype: Diffuse (Predominantly Small Cell) | + | + | + | - | - | - | - | - | CD10+/-; CD11c-; CD23-/+; CD43-; sIg+ (M+/-D > G > A); Bcl-2+ in follicles; organized FDC | t(14;18) w/bcl-2 (70-95%) |
| Marginal Zone B-Cell Lymphoma; 1)Extranodal: Low-grade B-cell lymphoma of MALT type (+/- monocytoid B-cells); 2) Nodal: (+/- monocytoid B-cells) | + | + | + | - | - | - | - | - | CD10-; CD11c+/-; CD23-; CD43-/+; sIg+ (M >G or A); IgD-; cIg+ (40%) | No bcl-1 or bcl-2 rg; +3 and/or t(11;18) reported in extranodal type |
| Splenic Marginal Zone Lymphoma, w/ or w/o Villous Lymphocytes (provisional entity) | + | + | + | - | - | - | - | - | CD10-; CD11c+/-; CD23-; CD43-/+; CD25-; sIg+ (M>G or A; lack IgD); cIg+ (40%); TRAP- | Not well studied; +3 nd |
| Hairy Cell Leukemia | + | + | + | - | - | - | - | - | CD10-; CD11c+ (st); CD23-; CD25+ (st); CD103+; sIg+ (M+/- D, G or A); FMC7+; TRAP+ (mj) | Ig HC & LC rg |
| Plasmacytoma/Plasma Cell myeloma | - | - | - | - | - | - | - | - | CD30+; CD38+; CD43+/-; CD45-/+; CD56+/-; sIg-; cIg+ (G, A, rare D/E; or LC only); HLADR/+; EMA-/+ | Ig HC & LC rg or deleted |
| Diffuse Large B-Cell Lymphoma | + | + | + | - | - | -/+ | - | - | CD10-/+; CD45+/-; sIg+/-; cIg-/+ | bcl-2 rg (30%); c-myc rg (rp); bcl-6 rg; EBV+ in PTLD, HIV |
| Primary Mediastinal (Thymic) Large B-Cell Lymphoma (Large B-Cell Lymphoma Subtype) | + | + | + | - | - | - | - | - | CD15-; CD30-/+; CD45+/-; sIg- | Ig HC & LC rg |
| Burkitt's Lymphoma | + | + | + | - | - | - | - | - | CD10+; CD23-; sIgM+ | t(8;14); t(2;8); or t(8;22) of c-myc |
| High-Grade B-Cell Lymphoma, Burkitt-like (provisional entity) | + | + | + | - | - | - | - | - | CD10- (us); sIg+/-; cIg ps | bcl-2 rg (30%); c-myc rg (un) |
| T Cell Lymphomas | ||||||||||
| Precursor T-Lymphoblastic Lymphoma/Leukemia (T-LBL) | - | - | - | +/- | +/- | +/- | + | CD4+/ CD8+ or CD4- / CD8- | CD1a+/-; cytoplasmic CD3; CD16 oc; CD57 oc; TdT+; Ig-; alpha-beta or gamma-delta or no TCRs | TCR rg (vr); Ig HC (ps) |
| T-Cell Chronic Lymphocytic Leukemia (T-CLL)/T-Prolymphocytic Leukemia (T-PLL) | - | - | - | + | + | + | + | CD4+ / CD8-(65%); CD4+/CD8+ (21%); CD4-/CD8+ rare | CD25- | clonal TCR rg: inv14(q11; q32) in 75%; +8q |
| T-Cell Large Granular Lymphocyte Leukemia (T-LGL) | - | - | - | + | + | - | - | CD4-/CD8+ | CD16+; CD25-; CD56-/+; CD57+/-; TCRalpha/betaR+ | clonal TCR rg |
| NK-Cell Large Granular Lymphocyte (LGL) Leukemia (NK-LGL) | - | - | - | + | - | - | - | - | CD16+; CD56+/-; CD57+/-; TCRalpha/beta- | TCR germ |
| Mycosis Fungoides/ Sézary Syndrome | - | - | - | + | + | + | 0.3 | CD4+/CD8- | CD25- (us) | clonal TCR rg |
| Peripheral T-Cell Lymphomas, Unspecified (Medium-, mixed Medium & Large-, Large-Cell) | - | ra | - | +/- | +/- | +/- | -/+ | CD4+ > CD8+;CD4-/CD8- ps | CD45RA+ & CD45RO- (ps) | TCR rg (us); Ig genes germ |
| Angioimmunoblastic T-Cell Lymphoma | - | - | - | + | + | + | + | CD4+ > CD8+ | expanded FDC surrounding venules | TCR rg (75%); Ig HC rg (10%); EBV genome + (of); +3 and/or +5 (ps) |
| Angiocentric Lymphoma | - | - | - | + | - (of) | +/- | +/- | either + | CD56+ (of) | TCR & Ig germ; EBV genome + (us) |
| Intestinal T-Cell Lymphoma (with or without Enteropathy) | - | - | - | + | + | + | + | CD4-/CD8+/- | CD103+ | clonal TCRbeta rg |
| Adult T-Cell Lymphoma/Leukemia (ATL/L) | - | - | - | + | + | + | - | CD4+ >> CD8+ | CD25+ | clonal TCR rg; clonal integrated HTLV-1 genome + |
| Anaplastic large Cell (CD30+) Lymphoma (T- and Null-Cell Types) | -/+ | -/+ | -/+ | +/- | -/+ | vr | vr | vr | CD15-/+; CD25+/-; CD30+; CD43-/+; CD45+/-; CD45RO-/+; CD68-5 EMA+/- | t(2;5); TCR rg (50-60%) |
| ALCL Hodgkin's-Like /Hodgkin's-related (provisional entity) | -/+ | -/+ | -/+ | +/- | -/+ | vr | vr | vr | CD15-/+; CD25+/-; CD30+; CD43-/+; CD45+/-; CD45RO-/+; CD68-5; EMA+/-6; EBV- | unknown |
| Hodgkin's Disease (HD) | ||||||||||
| Lymphocyte Predominance (Paragranuloma) HD | + | + | + | - | - | - | - | - | CD15-; CD30-/+; CD45+; CD57+ T-cells surround L&H cells; EMA+/-; Ig- (us); prom FDC mesh | Ig & TCR germ; EBV- (mj) |
| Nodular Sclerosis HD | - | - | - | - | - | - | - | - | CD15+/-; CD30+; CD45-; EMA- | Ig & TCR germ (us); EBV+ (40%) |
| Mixed Cellularity HD | - | - | - | - | - | - | - | - | CD15+/-; CD30+; CD45-; EMA- | Ig & TCR germ (us); EBV+ (60-70%) |
| Lymphocyte Depletion HD | - | - | - | - | - | - | - | - | CD15+/-; CD30+; CD45-; EMA- | Ig & TCR germ |
| Lymphocyte-Rich Classical HD (provisional entity) | Similar to Nodular Sclerosis and Mixed Cellularity HD | |||||||||
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