Below is a chart of the typical CD markers (cluster of differentiation) found on most lymphomas. These are just one tool the pathologist uses to make a diagnosis. First is the chart for B-cell types of lymphoma. Below that is the chart for T-cell lymphomas.
Click here for a chart of all CD markers and what they mean.
Marker Status | |||||||||||
Type | CD5 | CD10 | CD19 | CD20 | CD21 | CD22 | CD23 | CD43 | CD79a | sIg | cIg |
Follicular | 1 | 3 | 4 | 4 | 4 | 2 | 1 | 4 | 4 | 0 | |
Nodal marginal zone | 1 | 1 | 4 | 4 | 4 | 1 | 2 | 4 | M4, D1 | 2 | |
MALT | 1 | 1 | 4 | 4 | 4 | 1 | 2 | 4 | M4 | 2 | |
Splenic Marginal zone | 1 | 1 | 4 | 4 | 4 | 1 | 0 | 4 | M4 | 2 | |
CLL/SLL | 4 | 0 | 4 | 4 | 4 | 4 | 4 | 4 | D3 | 2 | |
Lymphoplasmacytic Waldenstroms |
1 | 1 | 4 | 4 | 4 | 0 | 3 | 4 | M4, D2 | 4 | |
Mantle Cell | 4 | 1 | 4 | 4 | 4 | 1 | 4 | 4 | M&D 4 | 0 | |
Precursor B-cell (lymphoblastic) |
4 | 3 | 4 | 4 | 4 | 0 | 0 | 4 | 0 | 0 | |
Diffuse large B-cell | 2 | 2 | 4 | 4 | 4 | 0 | 1 | 4 | |||
Mediastinal large cell | 2 | ||||||||||
Burkitt's | 1 | 4 | |||||||||
Intravascular B-cell | |||||||||||
* Footnote: 0 = negative, 1 = <10% positive, 2 10-50% positivity, 3 = 50-90% positivity and 4 = >90% positive |
Marker Status | |||||||
Type | CD3 | CD5 | CD7 | CD4 | CD8 | CD30 | NK16/56 |
T-prolymphocytic leukaemia | + | - | + | +(-) | -(+) | - | - |
T-large granular lymphoproliferative | + | - | + | - | + | - | +(-) |
Mycosis Fungoides | + | + | + | - | -(+) | -(+) | - |
Cutaneous ALCL | + | +(-) | +(-) | +(-) | - | ++ | -(+)/-(+) |
Primary systemic ALCL | +(-) | +(-) | +(-) | -(+) | -(+) | ++ | - |
Peripheral T-cell lymphoma, unspecified | +(-) | +(-) | -(+) | +(-) | -(+) | -(+) | -(+)/-(+) |
Subcutaneous panniculitis-like T-cell | + | + | + | -(+) | +(-) | -(+) | -/-(+) |
Hepatosplenic T-cell lymphoma | + | - | + | - | - | - | +/+(-) |
Angioimmunoblastic T-cell lymphoma | + | + | - | +(-) | -(+) | - | - |
Extranodal NK/Tcell lymphoma | S -, C + | - | -(+) | -(+) | - | - | -/+ |
Enteropathy-associated T-cell lymphoma | + | + | + | -(+) | +(-) | +(-) | - |
Adult T-cell leukaemia/lymphoma | + | + | - | +(-) | -(+) | +(-) | - |
Footnote: + = >90% positive: +(-) = >50% positive; -(+) = <50% positive; - = <10% positive. ALCL-Anaplastic large cell lymphoma; C=Cytoplasmic; S-Surface. |
Institute of Biomedical Science
The Cancer network Cancer management Handbook
Medscape (note: article valid only until November 2007 but still online in 2016) Mantle Cell Lymphoma: An Update for Clinicians CME)
http://www.medscape.com/viewarticle/548587_1
More on Pan B-cell markers (CD19, CD20, CD22, CD79a)
http://www.antibodybeyond.com/reviews/cell-markers/b-cell-marker.htm